Key result
Metoprolol blunts adrenaline-induced pressor effects and increases heart rate compared to propranolol.
Why the study?
The haemodynamic effects of adrenaline during selective versus non-selective beta-adrenoreceptor blockade combined with antihypertensive therapy were not well characterized.
Does selective beta-1 blockade (metoprolol) compared to non-selective blockade (propranolol) improve hemodynamic responses to adrenaline in hypertensive patients on combined therapy?
Population
27 hypertensive patients treated with beta-blockers plus diuretics or vasodilators
Comparison
Metoprolol (selective beta-1 blockade) vs propranolol (non-selective beta blockade) during adrenaline infusion
Design
Successive treatment comparison study
Authors
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May favor selective beta-1 blockade for hemodynamic stability with adrenaline; leaves open outcome impact in hypertension.
Does selective beta-1 blockade (metoprolol) compared to non-selective blockade (propranolol) improve hemodynamic responses to adrenaline in hypertensive patients on combined therapy?
Selective beta-1 blockade with metoprolol provides a more favorable hemodynamic response to acute stress (modeled by adrenaline) compared to non-selective blockade with propranolol in hypertensive patients.
Houben et al. (1979) studied Hypertension (n=27). Metoprolol vs. Propranolol was evaluated on Haemodynamic effects of adrenaline (blood pressure, heart rate, forearm blood flow, vascular resistance). During adrenaline infusion, metoprolol caused only a slight rise in blood pressure and increased heart rate, whereas propranolol caused a marked pressor effect and decreased heart rate.
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