Key result
Metoprolol and propranolol lower BP equally, suggesting the effect is mainly mediated via beta-1 blockade.
Why the study?
The comparative antihypertensive effects of non-selective and cardioselective beta-adrenoceptor blockers at rest and during exercise were unclear.
Does propranolol compared to metoprolol differentially reduce arterial blood pressure at rest and during exercise in patients with mild hypertension?
RCT (n=18)
Double-blind
Does propranolol compared to metoprolol differentially reduce arterial blood pressure at rest and during exercise in patients with mild hypertension?
Both non-selective and cardioselective beta-blockers reduce blood pressure to a similar extent at rest and during exercise, suggesting the antihypertensive effect is mainly mediated through beta-1 adrenoceptor blockade.
Supports equivalent BP control with cardioselective or nonselective beta-blockers in mild hypertension; confirms beta-1 blockade as primary mechanism.
1 The antihypertensive effects at rest and during physical exercise of the non-selective beta-adrenoceptor blocker propranolol and the cardioselective beta-adrenoceptor blocker metoprolol were compared in a double-blind cross-over study. 2 Eighteen patients with mild hypertension entered the trial. One patient was withdrawn from the study due to side effects on both drugs. 3 The two beta-adrenoceptor blockers were compared using doses earlier shown to have the same beta-adrenoceptor blocking potency, as measured by their effect on exercise tachycardia in healthy men. 4 Arterial blood pressure was reduced to the same extent by propranolol and metoprolol at rest as well as during submaximal work. 5 It is concluded that the antihypertensive effect of beta-adrenoceptor blockers is mainly mediated through blockade of the beta 1-adrenoceptors.
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Clausen et al. (1979) conducted an RCT in mild hypertension (n=18). Metoprolol vs. Propranolol was evaluated on Arterial blood pressure at rest and during submaximal work. Metoprolol and propranolol reduced arterial blood pressure to the same extent at rest and during submaximal work, suggesting the effect is mainly mediated through beta 1-adrenoceptor blockade.
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