Why the study?
Does single-dose beta-adrenoceptor blockade affect exercise tolerance and physiological responses to progressive exercise in healthy men?
Population
9 healthy men
Comparison
Single oral doses of 80 mg propranolol or 100 mg… vs Placebo
Design
RCT, double-blind
Follow-up
single dose
Authors
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Explains patient-reported fatigue on beta-blockers; RCT extends physiological basis from healthy volunteers.
Does single-dose beta-adrenoceptor blockade affect exercise tolerance and physiological responses to progressive exercise in healthy men?
Single doses of beta-blockers reduce exercise endurance and increase perceived exertion in healthy men, providing a physiological basis for the fatigue commonly reported by patients taking these medications.
Pearson et al. (1979) studied this question.
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