Key result
IV metoprolol limits exercise cardiac output drop vs propranolol, causing only ~5% reduction.
Why the study?
The differential effects of acute cardioselective versus non-selective beta-adrenergic blockade on left-ventricular volumes and vascular resistance at rest and during exercise were not fully characterized.
Absolute Event Rate: 5% vs 18%
No takes yet. Share an insight, caveat, or question.
May not apply to patients; leaves open differential beta-blocker effects on cardiac output in disease states.
Kelbaek et al. (1991) studied Healthy (n=8). Intravenous metoprolol vs. Intravenous propranolol was evaluated on Reduction in cardiac output during exercise. Intravenous metoprolol was superior to propranolol in limiting adverse cardiovascular changes during exercise, reducing cardiac output by 5% compared to 18%.
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