Key result
Low-dose epinephrine infusion induced a marked pressor effect and decreased heart rate during propranolol treatment, but only a slight blood pressure rise and increased heart rate during metoprolol.
Why the study?
Does low-dose epinephrine infusion cause different hemodynamic effects in hypertensive patients treated with propranolol versus metoprolol?
Does low-dose epinephrine infusion cause different hemodynamic effects in hypertensive patients treated with propranolol versus metoprolol?
Low-dose epinephrine infusion causes a marked pressor effect and bradycardia in patients on nonselective beta-blockers (propranolol) but not selective beta-blockers (metoprolol), which may influence the choice of antihypertensive therapy.
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May warrant caution with epinephrine in nonselective beta-blocker users; leaves open effects on clinical outcomes.
Houben et al. (1982) studied hypertension (n=5). Low-dose epinephrine infusion vs. Metoprolol vs propranolol background treatment was evaluated on Hemodynamic effects (blood pressure, heart rate, forearm blood flow). Low-dose epinephrine infusion induced a marked pressor effect and decreased heart rate during propranolol treatment, but only a slight blood pressure rise and increased heart rate during metoprolol.
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