The effects of metoprolol (40 and 80 mg orally as hydrochloride) and propranolol (40 mg orally as hydrochloride) were compared on the increase of heart rate and systolic blood pressure induced by physical exercise and infusion of isoprenaline. The two β‐blockers seemed to be equipotent in reducing heart rate and systolic blood pressure during exercise, while they differed considerably in their interaction with isoprenaline. Thus, the isoprenaline‐induced increase of the heart rate was blocked to a considerably greater extent after propranolol than after metoprolol. The reason for this is discussed and can be explained by the selectivity of metoprolol for β‐receptors.
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Johnsson et al. (1975) studied this question.
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