Key result
Intravenous infusion of epinephrine in healthy men increased forearm blood flow from 2.79 to 3.45 mL/100 forearm tissue/min (P<0.001), demonstrating a regional vasodilating effect.
Why the study?
Does intravenous epinephrine infusion alter forearm hemodynamics and arterial plasma norepinephrine in healthy men?
Does intravenous epinephrine infusion alter forearm hemodynamics and arterial plasma norepinephrine in healthy men?
Circulating epinephrine at concentrations produced by mental stress has a regional vasodilating effect in the human forearm, despite increasing sympathetic drive.
Answers are grounded in this paper and cite their sources.
May explain forearm vasodilation during mental stress; leaves open translation to clinical populations or sympathetic modulation.
Circulating catecholamines are widely considered to cause vasoconstriction. However, in the present study an intravenous infusion of 0.01 micrograms/kg/min epinephrine for 10 min in healthy men (n = 40, 20 to 40 years of age), which raised arterial plasma epinephrine from 100 +/- 13 to 231 +/- 22 pg/mL (mean +/- SE), increased forearm blood flow (FBF) from 2.79 +/- 0.17 to 3.45 +/- 0.25 mL/100 forearm tissue/min (P < .001), and decreased forearm vascular resistance (FVR) from 37.0 +/- 2.4 to 31.1 +/- 2.1 (arbitrary units). Further stepwise increase in epinephrine infusion rate progressively raised FBF (to a maximum 6.91 +/- 0.46) and decreased FVR (to minimum 16.7 +/- 2.0), and increased arterial plasma norepinephrine by more than 60% (P < .001). Thus, circulating epinephrine in concentrations that can be produced by mental stress has, despite its ability to increase sympathetic drive, a regional vasodilating effect in the human forearm.
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Kjeldsen et al. (1993) studied Healthy (n=40). Epinephrine vs. Baseline was evaluated on Forearm blood flow (FBF) (p=<0.001). Intravenous infusion of epinephrine in healthy men increased forearm blood flow from 2.79 to 3.45 mL/100 forearm tissue/min (P<0.001), demonstrating a regional vasodilating effect.
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