Key result
Epinephrine infusion augmented the systolic pressor response to psychosocial stress compared to placebo (+17 vs +10 mm Hg; p=0.02).
Why the study?
Does epinephrine infusion augment hemodynamic reactivity to mental stress in normotensive men?
RCT (n=14)
Double-blind
random order
Does epinephrine infusion augment hemodynamic reactivity to mental stress in normotensive men?
Absolute Event Rate: 17% vs 10%
p-value: p=0.02
High circulating epinephrine levels amplify acute systolic pressor responses to mental stress but do not cause prolonged augmentation of blood pressure responses.
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Epinephrine may amplify acute systolic BP reactivity to mental stress; extends mechanistic evidence on catecholamine modulation of hemodynamic responses.
Jern et al. (1991) conducted an RCT in Normotension (n=14). Epinephrine vs. Placebo was evaluated on systolic pressor response to psychosocial stress (p=0.02). Epinephrine infusion augmented the systolic pressor response to psychosocial stress compared to placebo (+17 vs +10 mm Hg; p=0.02).
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