Key result
Propranolol almost completely inhibits epinephrine-induced ST elevation and T wave inversion in canine hearts.
Why the study?
The electrophysiological effects of epinephrine and propranolol on the heart and their relation to anginal pain relief were investigated.
Do epinephrine and propranolol alter the electrophysiological properties of the in situ heart in anesthetized dogs?
Population
21 anesthetized dogs with in situ hearts
Comparison
Epinephrine infusion vs propranolol effects on epinephrine-induced changes
Design
Preclinical electrophysiological study
Follow-up
Seconds after infusion
Authors
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May support propranolol's role against catecholamine effects; hypothesis-generating in canine models and leaves open human translation.
Do epinephrine and propranolol alter the electrophysiological properties of the in situ heart in anesthetized dogs?
Propranolol inhibits epinephrine-induced abnormal electrophysiological changes in the heart, supporting its mechanism in relieving angina.
Prinzmetal et al. (1970) studied Healthy (animal model) (n=21). Propranolol and Epinephrine vs. Baseline / Epinephrine alone was evaluated on Changes in surface and intracellular electrograms (ST segment, T wave, MAP). Propranolol almost completely inhibited the abnormal surface and intracellular electrographic changes, such as ST segment elevation and T wave inversion, induced by epinephrine in the canine heart.
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