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August 1, 1968CirculationOpen Access

Effects of Beta-Adrenergic Blockade (Propranolol) on Left Ventricular Hemodynamics and the Electrocardiogram During Exercise-Induced Angina Pectoris

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Why the study?

Does intravenous propranolol improve left ventricular hemodynamics and prevent angina during exercise in patients with ischemic heart disease?

Population

n=9 patients with ischemic heart disease undergoing cardiac catheterization

Comparison

Intravenous propranolol vs Control exercise before propranolol administration

Design

Case_series

Follow-up

Acute (during cardiac catheterization)

Authors

EDEdward M. DwyerRutgers, The State University of New JerseyLWLeslie WienerCamden County CollegeJCJohn W. CoxGriffith University

Discussion

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Implication

May support propranolol for exertional angina; leaves open confirmation in randomized trials.

Structured PICO

Does intravenous propranolol improve left ventricular hemodynamics and prevent angina during exercise in patients with ischemic heart disease?

P
Population
n=9 patients with ischemic heart disease undergoing cardiac catheterization
I
Intervention
Intravenous propranolol
C
Comparator
Control exercise before propranolol administration (self-controlled baseline)
O
Outcome
Left ventricular hemodynamics (heart rate, cardiac output, mean systolic ejection rate, stroke volume, left ventricular systolic pressure, first derivative, work, LVEDP), electrocardiographic changes, and appearance of angina during exercisesurrogate

Intravenous propranolol improves exercise-induced angina and ischemic ECG changes by suppressing positive chronotropic and inotropic responses, reducing myocardial oxygen consumption.

Cite This Study

Dwyer et al. (1968) studied this question.

synapsesocial.com/papers/6a71542a6c240de38cdc1983https://doi.org/10.1161/01.cir.38.2.250
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparative Study of Nitroglycerin and Propranolol1967 · 102 citations
  2. 2Left Ventricular Hemodynamics in Exercise-Induced Angina Pectoris1968 · 170 citations
  3. 3Effects of beta-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man.1965 · 478 citations
  4. 4Effect of Left Ventricular Hypertension, Ischemia and Vasoactive Drugs on the Myocardial Distribution of Coronary Flow1967 · 151 citations
  5. 5THE EFFECTS OF SYMPATHECTOMY ON THE ELECTROCARDIOGRAM AND EFFORT TOLERANCE IN ANGINA PECTORIS1964 · 74 citations