April 1, 1982AJP Heart and Circulatory Physiology

alpha- and beta-Adrenergic effects of epinephrine on ventricular pacemakers in dogs

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Population

19 adult dogs with chronic complete heart block induced by the injection of formalin into the His bundle.

Comparison

Epinephrine infused intravenously in graded… vs Baseline ventricular rate and responses prior to…

Design

Preclinical

Authors

AHAllan J. HordofBoston Children's Hospital ERE. H. De RoseGerman Sport University Cologne PDPeter DaniloColumbia University

Discussion

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Implication

May unmask alpha-mediated ventricular slowing by low-dose epinephrine under beta-blockade; hypothesis-generating for human arrhythmia management.

Structured PICO

Population

19 adult dogs with chronic complete heart block induced by the injection of formalin into the His bundle (initial cohort of 15 dogs, plus 4 additional dogs).

Intervention

Epinephrine infused intravenously in graded doses of 0.01-10.0 micrograms/kg/min, following atropine (0.1 mg/kg IV). Subsequent interventions included beta-blockade with propranolol (0.5 mg/kg IV) and alpha-blockade with phentolamine.

Comparator

Baseline ventricular rate and responses prior to the administration of adrenergic blocking agents (within-subject comparisons).

Outcome

Change in ventricular rate and arterial blood pressure.surrogate

Epinephrine exerts an alpha-adrenergic effect that slows ventricular automaticity, which can be unmasked by beta-blockade and is independent of blood pressure changes.

Cite This Study

Hordof et al. (1982) studied this question.

synapsesocial.com/papers/6a71d41d35aa2c282ce2f34d https://doi.org/10.1152/ajpheart.1982.242.4.h677

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Implication

May unmask alpha-mediated ventricular slowing by low-dose epinephrine under beta-blockade; hypothesis-generating for human arrhythmia management.

alpha- and beta-Adrenergic effects of epinephrine on ventricular pacemakers in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

alpha- and beta-Adrenergic effects of epinephrine on ventricular pacemakers in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider