Population
23 chloralose-anesthetized sinoaortic and vagotomized dogs
Comparison
Graded infusions of norepinephrine and… vs Different pharmacological conditions
Design
Preclinical
Authors
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May indicate alpha-1 effects on Purkinje refractoriness during beta-blockade in canines; leaves open human translation and physiological relevance.
Alpha-adrenergic stimulation prolongs the relative refractory period of the Purkinje system but not the ventricular muscle in intact canine hearts, though this may be a pharmacological rather than physiological effect.
Martins et al. (1989) studied this question.
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