September 1, 1978British Journal of PharmacologyOpen Access

Characterization of Adrenoceptors Mediating Positive Inotropic Responses in the Ventricular Myocardium of the Dog

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Population

Dog heart preparations

Design

Preclinical

Authors

MEMakoto EndohYamagata Prefectural Central Hospital TSTetsuo ShimizuNihon University TYTeruyuki YanagisawaTohoku University

Discussion

Member takes

Implication

Reinforces beta-adrenoceptor focus in canine inotropy models; leaves open species differences and human translation.

Structured PICO

Population

Dog heart preparations (blood-perfused papillary muscles, isolated strips of ventricular myocardium, and sinus node preparations)

Intervention

Adrenoceptor agonists and antagonists (including phenylephrine, isoprenaline, pindolol, phentolamine, dopamine, tyramine, desipramine, papaverine, methoxamine, clonidine, noradrenaline, and adrenaline)

Outcome

Inotropic and chronotropic responsessurrogate

This preclinical study demonstrates that positive inotropic responses in the dog ventricle are mediated by beta-adrenoceptors rather than alpha-adrenoceptors.

Cite This Study

Endoh et al. (1978) studied this question.

synapsesocial.com/papers/6a90e8b54290e6989a36067f https://doi.org/10.1111/j.1476-5381.1978.tb08640.x

View Full Paper

Ask AI

Bookmark

Characterization of Adrenoceptors Mediating Positive Inotropic Responses in the Ventricular Myocardium of the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of Adrenoceptors Mediating Positive Inotropic Responses in the Ventricular Myocardium of the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider