Population
Dog isolated papillary muscle and sinus node preparations perfused with arterial blood from a donor dog, and…
Comparison
Dopamine with or without pretreatments vs Noradrenaline and nerve stimulation
Design
Preclinical
Authors
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May inform experimental inotrope models; leaves open translation to human shock or HF dosing.
Dopamine exerts positive inotropic and chronotropic effects on the dog heart via direct and indirect beta-adrenoceptor stimulation, with a preferential effect on ventricular contractility over sinus rate.
Makoto Endoh (1975) studied this question.
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