Key result
Dopamine demonstrated significant positive inotropic and chronotropic effects in dog heart-lung preparations, including an 18% average increase in heart rate.
Why the study?
Does dopamine improve hemodynamic parameters in dog heart-lung preparations?
Does dopamine improve hemodynamic parameters in dog heart-lung preparations?
Dopamine demonstrates significant positive inotropic and chronotropic effects in dog heart-lung preparations, with potentially longer duration and less subsequent cardiac depression than levarterenol.
Answers are grounded in this paper and cite their sources.
Early animal data show cardiac stimulation by dopamine; leaves open translation to human inotrope use.
The cardiac effects of dopaminie, an epinephrine precursor, were studied in 20 dog heart-lung preparations. In 8 uncontrolled rate preparations. dopamine, 0.5 to 1 mg., increased the heart rate an average of 18 pet cent. In controlled rate preparations. dopamine, 100 to 500 µg ., consistently increased ventricular contractile force, cardiac output and blood pressure; there was a consistent decrease of right and left atrial pressure. Comparable hemodynamic effects were produced by 1 to 5 µg . of levarterenol, except that the effects of dopamine tended to be of longer duration and were less likely to be followed by cardiac depression. It is concluded that doparnine has significant positive inotropic and chronotropic effects in the dog heart-lung preparation.
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Holmes et al. (1962) studied this question. Dopamine vs. Levarterenol was evaluated on Cardiac effects (heart rate, ventricular contractile force, cardiac output, blood pressure). Dopamine demonstrated significant positive inotropic and chronotropic effects in dog heart-lung preparations, including an 18% average increase in heart rate.
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