What question did this study set out to answer?

The study aims to assess how intravenous dopamine infusions affect coronary blood flow and myocardial oxygen consumption in dogs.

May 1, 1969Circulation ResearchOpen Access

Dopamine-Induced Alterations in Coronary Hemodynamics in Dogs

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Why the study?

Does intravenous dopamine alter coronary blood flow and myocardial oxygen consumption in open-chest dogs?

Population

17 open-chest dogs anesthetized with chloralose

Comparison

Intravenous infusions of dopamine in doses… vs Control (baseline before dopamine infusion)

Design

Preclinical

Authors

HBHarold L. BrooksBrigham and Women's Hospital PSPaul D. SteinVascular / Pulmonary Vascular JMJames L. MatsonBaylor University Medical Center

Discussion

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Implication

Dopamine's demand-driven coronary effects in dogs extend foundational physiology; leaves open translation to human dosing and ischemia risk.

Key Points

The study aims to assess how intravenous dopamine infusions affect coronary blood flow and myocardial oxygen consumption in dogs.
Intravenous infusions of dopamine (5 to 100 µg/kg/min) administered to 17 open-chest dogs.
Coronary flow measured using an electromagnetic flowmeter and myocardial oxygen consumption assessed.
Evaluated hemodynamic changes including stroke volume and left ventricular dP/dt.
Dopamine increased coronary flow up to 365% at 80 µg/kg/min compared to control (28 to 129 ml/min).
Marked increases in stroke volume and left ventricular dP/dt were observed alongside increased coronary flow.
Mean aortic pressure and heart rate showed minimal changes at doses below 10 µg/kg/min but increased steadily at doses above 15 µg/kg/min.

Structured PICO

Does intravenous dopamine alter coronary blood flow and myocardial oxygen consumption in open-chest dogs?

Population

17 open-chest dogs anesthetized with chloralose

Intervention

Intravenous infusions of dopamine in doses ranging from 5 to 100 µg/kg/min

Comparator

Control (baseline before dopamine infusion)

Outcome

Left circumflex coronary blood flow and myocardial oxygen consumptionsurrogate

Intravenous dopamine potently stimulates coronary blood flow and myocardial contractility, with coronary vasodilation occurring secondary to increased myocardial oxygen demands rather than primary vasodilation.

Cite This Study

Brooks et al. (1969) studied this question.

synapsesocial.com/papers/6a1e86fc40bc8a3dd769052d https://doi.org/10.1161/01.res.24.5.699

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Implication

Dopamine's demand-driven coronary effects in dogs extend foundational physiology; leaves open translation to human dosing and ischemia risk.

Dopamine-Induced Alterations in Coronary Hemodynamics in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Dopamine-Induced Alterations in Coronary Hemodynamics in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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