Key result
In pithed rats, adrenaline and alpha1-adrenoceptor agonists exert an alpha-adrenoceptor-mediated increase in cardiac contractility that is not shared by noradrenaline.
Population
Pithed rats
Comparison
Selective alpha1-adrenoceptor agonists… vs Noradrenaline or baseline
Design
Preclinical
Authors
Loading...
Hypothesis-generating for differential catecholamine inotropy; does not support clinical extrapolation or practice change.
This in vivo study in pithed rats demonstrates that adrenaline and alpha1-agonists induce alpha-adrenoceptor-mediated positive inotropy, an effect not shared by noradrenaline.
Broadley et al. (1999) studied this question. Alpha-adrenoceptor agonists and adrenaline vs. Noradrenaline was evaluated on Cardiac contractility (maximum rate of rise of left ventricular pressure, dP/dt(max)). In pithed rats, adrenaline and alpha1-adrenoceptor agonists exert an alpha-adrenoceptor-mediated increase in cardiac contractility that is not shared by noradrenaline.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: