Why the study?
Does chronic oral prazosin treatment alter myocardial chronotropic and inotropic responsiveness to adrenoreceptor agonists in rats?
Population
Rats (isolated right atria and left ventricular papillary muscles)
Comparison
Prazosin administered orally for 5 weeks vs Vehicle administered orally for 5 weeks
Design
Preclinical
Follow-up
5 weeks
Authors
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Chronic prazosin may induce myocardial alpha-1 supersensitivity in rats; hypothesis-generating and should not alter clinical practice.
Does chronic oral prazosin treatment alter myocardial chronotropic and inotropic responsiveness to adrenoreceptor agonists in rats?
Chronic alpha-1 adrenoreceptor blockade with prazosin in rats induces supersensitivity of alpha-1-mediated inotropism without affecting beta-mediated responses.
Margaret D. Brown (1989) studied this question.
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