June 1, 1989AJP Heart and Circulatory Physiology

An unusual receptor mediates adenosine-induced SA nodal bradycardia in dogs

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Population

Conscious dogs with chronically implanted cardiovascular instrumentation under autonomic blockade, and…

Design

Preclinical

Authors

FBFrancis L. BelloniWestchester Medical Center LBLuiz BelardinelliElectrophysiology CHC HalperinHospital Ernesto Dornelles

Discussion

Member takes

Implication

Indicates atypical adenosine receptor in canine SA node; leaves open translation to human physiology or therapy.

Structured PICO

Population

Conscious dogs with chronically implanted cardiovascular instrumentation under autonomic blockade, and isolated perfused dog right atrial preparations including the sinoatrial node.

Intervention

Intravenous bolus injections or intrasinoatrial node artery infusions of various adenosine analogues (including NECA, 2-chloroadenosine, adenosine, R-PIA, N6-cyclohexyladenosine, 2-phenylaminoadenosine, N6-cyclopentyladenosine), antagonists (aminophylline, XAC), and uptake inhibitors (dipyridamole).

Outcome

Reduction in heart rate (negative chronotropic effect) and coronary vasodilatation.surrogate

The negative chronotropic effect of adenosine in the canine sinoatrial node is mediated by a receptor with pharmacological properties distinct from typical A1 or A2 receptors.

Cite This Study

Belloni et al. (1989) studied this question.

synapsesocial.com/papers/6a762fe5b515f78917fbe1cc https://doi.org/10.1152/ajpheart.1989.256.6.h1553

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An unusual receptor mediates adenosine-induced SA nodal bradycardia in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

An unusual receptor mediates adenosine-induced SA nodal bradycardia in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider