Key result
Intravenous adenosine reduced heart rate by 22% at baseline and by 36% during electrical vagal stimulation, indicating its inhibitory action is masked by vagal withdrawal due to hypotension.
Population
Conscious and anaesthetised, vagotomised dogs
Comparison
Intravenous adenosine injections during constant… vs Adenosine without concomitant electrical…
Design
Preclinical
Authors
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Clarifies adenosine chronotropy requires hypotension controls in models; extends mechanistic insights but leaves open human vagal applicability.
Absolute Event Rate: 36% vs 22%
The apparent parasympathetic inhibition of adenosine-induced heart rate slowing in dogs is due to withdrawal of vagal tone secondary to adenosine-induced hypotension, rather than direct cholinergic inhibition.
Belloni et al. (1989) studied this question. Intravenous adenosine vs. Baseline / normal vagal tone was evaluated on Heart rate reduction. Intravenous adenosine reduced heart rate by 22% at baseline and by 36% during electrical vagal stimulation, indicating its inhibitory action is masked by vagal withdrawal due to hypotension.
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