Population
21 barbiturate anaesthetised mongrel dogs with bilateral cervical vagotomy and stellectomy
Comparison
Adenosine combined with vagal stimulation vs Baseline conditions
Design
Preclinical
Authors
Loading...
Vagal tone potentiates adenosine sinus node effects in animals; extends mechanistic data but leaves open human relevance.
Background vagal tone modulates the negative chronotropic action of adenosine, and increased extracellular adenosine potentiates the depressant action of the vagus nerve on the sinus node.
Pelleg et al. (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: