Why the study?
Does autonomic tone influence the negative chronotropic effect of adenosine on the sinus node in patients without structural heart disease?
Population
11 patients without structural heart disease undergoing a clinically indicated electrophysiology procedure
Comparison
12-mg bolus of adenosine administered during… vs Sinus cycle length before adenosine…
Design
Other
Authors
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May accentuate adenosine sinus node effects during beta-stimulation; hypothesis-generating for autonomic modulation in patients without heart disease.
Does autonomic tone influence the negative chronotropic effect of adenosine on the sinus node in patients without structural heart disease?
The negative chronotropic effect of adenosine on the sinus node is accentuated by beta-adrenergic stimulation but unaffected by beta-adrenergic or combined blockade.
Kou et al. (1999) studied this question.
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