January 1, 1976Japanese Heart JournalOpen Access

Differences in Chronotropic and Inotropic Responses of Canine Atrial Muscle and SA Node Pacemaker Activity to Adenosine and ACh

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Population

Isolated right atrium from dog heart, perfused with heparinized arterial blood from a support dog…

Design

Preclinical

Authors

SCShigetoshi ChibaMount Sinai Hospital

Discussion

Member takes

Implication

Differential thresholds in canine atria caution against human extrapolation; leaves open receptor-specific mechanisms for targeted therapies.

Structured PICO

Population

Isolated right atrium from dog heart, perfused with heparinized arterial blood from a support dog anesthetized with 30 mg/Kg of sodium pentobarbital

Intervention

Adenosine (0.3-100 mug) and Acetylcholine (0.01-10 mug) administered into the sinus node artery, with or without caffeine, atropine, or physostigmine

Outcome

Chronotropic and inotropic responses (SA nodal pacemaker activity and atrial contractile force)surrogate

Adenosine and ACh both depress SA nodal pacemaker activity and atrial contractile force in canine models, but exhibit different dose-response profiles and receptor sensitivities.

Cite This Study

Shigetoshi Chiba (1976) studied this question.

synapsesocial.com/papers/6a90a148f5c79ce9992dc5d4 https://doi.org/10.1536/ihj.17.73

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Implication

Differential thresholds in canine atria caution against human extrapolation; leaves open receptor-specific mechanisms for targeted therapies.

Differences in Chronotropic and Inotropic Responses of Canine Atrial Muscle and SA Node Pacemaker Activity to Adenosine and ACh

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differences in Chronotropic and Inotropic Responses of Canine Atrial Muscle and SA Node Pacemaker Activity to Adenosine and ACh

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider