Why the study?
Does continuous infusion of adenosine alter the chronotropic and inotropic responses to bolus adenosine and acetylcholine in isolated canine right atria?
Population
isolated, blood-perfused canine right atria
Design
Preclinical
Authors
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Does not support changing adenosine protocols in humans; leaves open mechanisms of desensitization and cholinergic potentiation in cardiac tissue.
Does continuous infusion of adenosine alter the chronotropic and inotropic responses to bolus adenosine and acetylcholine in isolated canine right atria?
Continuous adenosine infusion causes acute desensitization to subsequent adenosine boluses while potentiating cholinergic responses in isolated canine atria.
Tsuboi et al. (2000) studied this question.
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