January 1, 1972The Japanese Journal of PharmacologyOpen Access

Differences in Chronotropic and Dromotropic Responses of the Sa and Av Nodes to Adenosine and Acetylcholine

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Population

Dog and guinea-pig models using selective perfusion systems of the sinus and AV node arteries

Design

Preclinical

Authors

SCShigetoshi ChibaMount Sinai Hospital KHKoroku HashimotoFood and Drug Safety Center

Discussion

Member takes

Implication

Provides a selective perfusion method for nodal adenosine effects in animals; leaves open translation to human electrophysiology.

Structured PICO

Population

Dog and guinea-pig models using selective perfusion systems of the sinus and AV node arteries

Intervention

Adenosine and acetylcholine administered via selective perfusion

Outcome

Effects on AV conductivity in comparison with the automaticity of the SA or AV node (chronotropic and dromotropic responses)surrogate

This preclinical study describes a selective double perfusion method to examine the differential chronotropic and dromotropic effects of adenosine on SA and AV node function in animal models.

Cite This Study

Chiba et al. (1972) studied this question.

synapsesocial.com/papers/6a7473356a5eb4b8f5090d76 https://doi.org/10.1254/jjp.22.273

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Differences in Chronotropic and Dromotropic Responses of the Sa and Av Nodes to Adenosine and Acetylcholine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differences in Chronotropic and Dromotropic Responses of the Sa and Av Nodes to Adenosine and Acetylcholine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider