Adenosine causes bradycardia in pacing-induced cardiac failure.

Mongrel dogs instrumented with indwelling catheters, manometers, and ventricular pacing electrodes, subjected to continuous ventricular pacing to induce congestive heart failure.

Systemic injection of adenosine during the development of pacing-induced heart failure (up to 4 weeks).

Response to adenosine injections before the pacing regimen began (normal state).

Heart rate response to adenosine injection.surrogate