Central and Splanchnic Hemo dynamics in the Dog during Controlled Hypotension with Adenosine

10 artificially ventilated dogs under neurolept anesthesia

Adenosine administered as a continuous infusion (in aorta n=3, in inferior vena cava n=3, or after dipyridamole pretreatment n=4) to maintain mean arterial blood pressure at approximately 50 mmHg for 20 minutes

Baseline observations before controlled hypotension

Central and splanchnic hemodynamic changes (including systemic vascular resistance, preportal vascular resistance, hepatic arterial vascular resistance, cardiac output, and heart rate) after 20 minutes of controlled hypotensionsurrogate