September 1, 1985AJP Heart and Circulatory Physiology

Apparent reduction in baroreflex sensitivity to adenosine in conscious dogs

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Why the study?

Does adenosine alter baroreflex sensitivity compared to nitroglycerin in conscious dogs?

Population

Conscious dogs

Comparison

Adenosine (5.0 mumol/kg) vs Nitroglycerin

Design

Preclinical

Authors

THThomas H. HintzeHeart Failure / Cardiomyopathy FBFrancis L. BelloniWestchester Medical Center JHJoan E. HarrisonUniversity of Colorado Hospital

Discussion

Member takes

Implication

Does not support clinical extrapolation from dogs; leaves open human baroreflex effects of vasodilators.

Structured PICO

Does adenosine alter baroreflex sensitivity compared to nitroglycerin in conscious dogs?

Population

Conscious dogs

Intervention

Adenosine (5.0 mumol/kg)

Comparator

Nitroglycerin (25 micrograms/kg) (equihypotensive doses)

Outcome

Heart rate and baroreflex sensitivitysurrogate

Adenosine alters normal baroreflex function in conscious dogs by reducing the tachycardia that normally follows a fall in systemic arterial pressure.

Cite This Study

Hintze et al. (1985) studied this question.

synapsesocial.com/papers/6a762fe5b515f78917fbe1d2 https://doi.org/10.1152/ajpheart.1985.249.3.h554

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Apparent reduction in baroreflex sensitivity to adenosine in conscious dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Apparent reduction in baroreflex sensitivity to adenosine in conscious dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider