Why the study?
Does induction of anesthesia with diazepam or midazolam affect baroreflex control of heart rate and plasma catecholamine levels?
Population
20 subjects (Group 1 n=10, Group 2 n=10) undergoing induction of anesthesia (likely dogs based on title)
Comparison
Diazepam 0.4 mg/kg IV or Midazolam 0.3 mg/kg IV vs Baseline measurements (before drug administration)
Design
Preclinical
Follow-up
15 minutes post-administration
Authors
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May warrant caution with benzodiazepine induction in unstable patients; leaves open translation of baroreflex effects to human anesthesia.
Does induction of anesthesia with diazepam or midazolam affect baroreflex control of heart rate and plasma catecholamine levels?
Diazepam and midazolam used for anesthesia induction cause a transient depression of baroreflex function and a sustained decrease in sympathetic tone.
Kien et al. (1986) studied this question.
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