Key result
Midazolam 0.2 mg/kg i.v. statistically attenuated the increase in plasma catecholamines during a nitroprusside-induced hypotensive challenge in anesthetized dogs.
Why the study?
Does midazolam reduce the physiological and hormonal responses to a nitroprusside-induced hypotensive challenge in anesthetized dogs?
Population
Dogs anesthetized with enflurane-nitrous oxide-oxygen undergoing a nitroprusside-induced hypotensive challenge
Design
Preclinical
Authors
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Does not support changes to human anesthetic practice; leaves open translation of catecholamine attenuation to clinical settings.
Does midazolam reduce the physiological and hormonal responses to a nitroprusside-induced hypotensive challenge in anesthetized dogs?
Midazolam attenuates the catecholamine response to hypotensive stress during anesthesia in a canine model, similar to diazepam and fentanyl.
Silas N. Glisson (1987) studied Nitroprusside-induced hypotensive challenge. Midazolam was evaluated on Plasma levels of epinephrine, norepinephrine, cortisol, renin activity, and hemodynamic performance. Midazolam 0.2 mg/kg i.v. statistically attenuated the increase in plasma catecholamines during a nitroprusside-induced hypotensive challenge in anesthetized dogs.
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