Why the study?
Does midazolam for induction of anaesthesia reduce glycaemic and adrenocortical responses to lower pelvic surgery in female patients compared to thiopentone?
Does midazolam for induction of anaesthesia reduce glycaemic and adrenocortical responses to lower pelvic surgery in female patients compared to thiopentone?
Midazolam induction does not blunt the glycaemic or adrenocortical stress responses to lower pelvic surgery in women compared to thiopentone.
Midazolam induction was not associated with blunted stress responses in pelvic surgery; leaves open whether alternative agents or settings differ.
The effect of midazolam, for induction of anaesthesia, on the glycaemic and adrenocortical responses to lower pelvic surgery in female patients has been studied and compared with a comparable group of patients receiving thiopentone. Although midazolam has been shown to obtund adrenaline and noradrenaline release to electrical or surgical stress in the rat and dog, there was no blunting of the glycaemic response to surgery in man. Plasma cortisol levels in response to surgery and anaesthesia were comparable in the two groups of patients.
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Dawson et al. (1986) studied this question.
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