Key result
Midazolam administration (0.1 mg/kg) decreased left ventricular contractility and reduced mean arterial pressure (89 to 76 mm Hg, P<0.0001) without changing cardiac index.
Why the study?
Does midazolam affect left ventricular pump performance and contractility in patients undergoing coronary artery bypass grafting?
Population
40 patients undergoing coronary artery bypass grafting, including 24 with depressed global left ventricular…
Comparison
Midazolam 0.1 mg/kg vs Baseline (during inhalation of 100% O2)
Design
Cohort
Authors
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Midazolam may reduce LV contractility and MAP in CABG patients without altering cardiac index; leaves open relevance for those with low EF.
Does midazolam affect left ventricular pump performance and contractility in patients undergoing coronary artery bypass grafting?
Midazolam administration in patients undergoing CABG decreases LV contractility without affecting overall cardiac pump performance, even in those with depressed ejection fraction.
Messina et al. (1995) studied Coronary artery disease (n=40). Midazolam vs. Baseline was evaluated on Left ventricular pump performance and contractility. Midazolam administration (0.1 mg/kg) decreased left ventricular contractility and reduced mean arterial pressure (89 to 76 mm Hg, P<0.0001) without changing cardiac index.
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