February 1, 1983AJP Heart and Circulatory Physiology
Arterial baroreceptors have minimal physiological effects on adrenal medullary secretion
Why the study?
Does arterial baroreceptor reflex activity affect adrenal medullary secretion of catecholamines in dogs?
Population
Mongrel dogs
Comparison
Hemorrhage, intravenous nitroglycerin-induced… vs Sham-operated control dogs and baseline
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Baroreflex exerts minimal control over adrenal catecholamines in conscious dogs; leaves open translation to human physiology and practice.
Structured PICO
Does arterial baroreceptor reflex activity affect adrenal medullary secretion of catecholamines in dogs?
P
Population
Mongrel dogs (including conscious dogs with surgically denervated hearts, sham-operated control dogs, and conscious dogs with aortic arch denervation but intact cardiac nerves)
I
Intervention
Hemorrhage (16% blood volume removed), intravenous nitroglycerin-induced hypotension, and occlusion of common carotid arteries for 5 min
C
Comparator
Sham-operated control dogs (for hemorrhage and nitroglycerin experiments) and baseline (for carotid occlusion)
O
Outcome
Heart rate changes and plasma epinephrine and norepinephrine concentrationssurrogate
The arterial baroreceptor reflex exerts minimal effects on adrenal medullary catecholamine secretion during physiological adjustments in conscious dogs.
Cite This Study
Fater et al. (1983) studied this question.