Key result
Chronic systemic administration of aldosterone in dogs significantly blunted the baroreflex slope compared to baseline (9.1 vs 13.3 for nitroglycerin, P<0.01).
Why the study?
Does chronic systemic administration of aldosterone depress baroreflex function in conscious dogs?
Population
Conscious dogs (n=6 in the primary intervention group)
Comparison
Aldosterone administered via implanted osmotic… vs Sham group and an aldosterone plus…
Design
Preclinical
Follow-up
10 days
Authors
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Hypothesis-generating for aldosterone's baroreflex effects in hypertension; human studies needed before clinical relevance.
Does chronic systemic administration of aldosterone depress baroreflex function in conscious dogs?
Absolute Event Rate: 9.1% vs 13.3%
p-value: p=< .01
Chronic systemic administration of aldosterone depresses baroreceptor reflex function in dogs, an effect that can be partially restored by Na+,K+-ATPase inhibition.
Weizong Wang (1994) studied Baroreceptor reflex function (n=6). Aldosterone vs. Baseline (before administration), sham (saline), and aldosterone plus spironolactone was evaluated on Slope of the relation between systolic arterial pressure and heart rate (baroreflex slope) (p=< .01). Chronic systemic administration of aldosterone in dogs significantly blunted the baroreflex slope compared to baseline (9.1 vs 13.3 for nitroglycerin, P<0.01).
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