Why the study?
Does acute intravenous aldosterone administration alter autonomic nervous system and baroreflex function in healthy humans?
Population
9 healthy subjects
Comparison
Intravenous aldosterone (100 microg) vs Placebo
Design
RCT, double-blind
Follow-up
acute (on the experimental day)
Authors
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May modulate autonomic function in this animal model; leaves open human translation and clinical relevance.
Does acute intravenous aldosterone administration alter autonomic nervous system and baroreflex function in healthy humans?
Acute aldosterone administration in healthy humans increases cardiac vagal activity and enhances the heart rate response to baroreceptor deactivation without affecting basal sympathetic nerve activity.
Heindl et al. (2005) studied this question.
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