Why the study?
Does aldosterone injection alter hemodynamic parameters in healthy male volunteers depending on their preexisting adrenergic state?
Population
18 healthy male volunteers
Comparison
Aldosterone injection after pretreatment with… vs Placebo injection after pretreatment with the…
Design
RCT, randomized, 8-fold cross-over, double blind
Follow-up
45 min
Authors
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Aldosterone rapidly modulates BP by adrenergic state; extends nongenomic mineralocorticoid effects to human hemodynamics.
Does aldosterone injection alter hemodynamic parameters in healthy male volunteers depending on their preexisting adrenergic state?
Aldosterone exerts rapid, nongenomic effects on blood pressure that vary depending on the preexisting adrenergic state, including blunting the blood pressure-lowering effect of esmolol.
Schmidt et al. (2001) studied this question.
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