Why the study?
Does intravenous aldosterone rapidly alter hemodynamic parameters in patients with suspected coronary heart disease?
Population
17 patients with suspected coronary heart disease undergoing cardiac catheterization
Comparison
Aldosterone 1 mg IV vs Placebo
Design
RCT, randomized parallel trial, double-blind, placebo-controlled
Follow-up
10 minutes
Authors
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Alerts to acute hemodynamic effects during IV aldosterone in suspected CHD; extends evidence for rapid nongenomic mineralocorticoid actions.
Does intravenous aldosterone rapidly alter hemodynamic parameters in patients with suspected coronary heart disease?
Intravenous aldosterone produces rapid, nongenomic hemodynamic effects, including changes in systemic vascular resistance and cardiac output, within minutes in patients with suspected coronary heart disease.
Wehling et al. (1998) studied this question.
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