Why the study?
Does aldosterone injection alter systemic vascular resistance and heart rate variability in healthy male volunteers?
Population
12 healthy male volunteers
Comparison
Injection of 0.05 mg or 0.5 mg aldosterone vs Placebo
Design
RCT, double blind, placebo-controlled
Follow-up
8 hours
Authors
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Rapid aldosterone effects on SVR detectable noninvasively in healthy men; extends nongenomic evidence and supports trials in cardiovascular disease.
Does aldosterone injection alter systemic vascular resistance and heart rate variability in healthy male volunteers?
Aldosterone exerts rapid, nongenomic cardiovascular effects, including an early increase and later decrease in systemic vascular resistance, detectable by noninvasive techniques.
Schmidt et al. (1999) studied this question.
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