Why the study?
Do aldosterone and spironolactone have rapid hemodynamic effects on contractility in the isolated working rat heart?
Population
Isolated working rat heart (Langendorff-Neely technique)
Comparison
Perfusion with aldosterone and/or spironolactone vs Baseline or each agent perfused alone
Design
Preclinical
Follow-up
2 to 4 minutes
Authors
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Rapid inotropic effects in rat hearts do not inform clinical practice; leaves open nongenomic mechanisms in heart failure.
Do aldosterone and spironolactone have rapid hemodynamic effects on contractility in the isolated working rat heart?
Aldosterone and spironolactone both demonstrate rapid, positive inotropic actions on the myocardium through potentially different pathways, which may contribute to the beneficial effects of spironolactone in heart failure.
Barbato et al. (2002) studied this question.
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