Why the study?
Does spironolactone improve myocardial function in hypertensive patients with suspected diastolic heart failure?
Does spironolactone improve myocardial function in hypertensive patients with suspected diastolic heart failure?
Spironolactone 25 mg/d for 6 months improves echocardiographic measures of myocardial function in hypertensive patients with diastolic heart failure, independent of blood pressure changes.
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Spironolactone may improve myocardial function in hypertensive diastolic HF; extends aldosterone antagonism evidence to strain parameters in RCT.
Mottram et al. (2004) studied this question.
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