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September 1, 1976American Journal of Physiology-Legacy Content

Pathways regulating cardiovascular changes during volume loading in awake dogs

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Why the study?

Does sympathetic denervation alter cardiovascular responses to acute volume loading in conscious dogs?

Population

15 normally innervated conscious dogs

Comparison

Acute volume loading with various nerve sections… vs Normally innervated state (baseline)

Design

Preclinical

Authors

VBV. S. BishopThe University of Texas Health Science Center at San AntonioDPD.A. PetersonUniversity of California System

Discussion

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Implication

Sympathetic modulation contributes to reflex tachycardia during volume loading in dogs; hypothesis-generating for autonomic control in humans, requires clinical validation.

Structured PICO

Does sympathetic denervation alter cardiovascular responses to acute volume loading in conscious dogs?

P
Population
15 normally innervated conscious dogs
I
Intervention
Acute volume loading with various nerve sections (bilateral baroreceptor denervation, dorsal root sections T1-T5, left/right/bilateral ansa subclavia section) and intravenous epinephrine
C
Comparator
Normally innervated state (baseline)
O
Outcome
Cardiovascular responses (mean arterial pressure, heart rate, cardiac output, peripheral resistance)surrogate

The primary efferent pathway for reflex tachycardia during volume loading is via the vagus nerve, but responses are modulated by sympathetic neural activity.

Cite This Study

Bishop et al. (1976) studied this question.

synapsesocial.com/papers/6a828c4f8ddd99b9b5239c39https://doi.org/10.1152/ajplegacy.1976.231.3.854
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of acute intravenous volume loading on haemodynamics and aortic baroreceptor activity in dogs1989 · 3 citations
  2. 2Reduced baroreflex sensitivity with volume loading in conscious dogs.1975 · 120 citations
  3. 3Role of arterial baroreceptors in mediating cardiovascular response to exercise1976 · 57 citations
  4. 4Cardiopulmonary reflexes and blood pressure in exercising sinoaortic-denervated dogs1984 · 34 citations
  5. 5Control of sympathetic nerve activity by vagal mechanoreflexes is blunted in heart failure.1992 · 88 citations