Effect of acute intravenous volume loading on haemodynamics and aortic baroreceptor activity in dogs

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Population

11 anaesthetized and instrumented beagles

Design

Preclinical

Authors

Discussion

Highlights peripheral vasodilation in animal heart rate responses to volume loading; leaves open human translation.

Population

11 anaesthetized and instrumented beagles

Intervention

Acute intravenous volume loading with isotonic saline (20% of estimated blood volume) infused over 60-90 seconds

Outcome

Haemodynamics (aortic pressure, diameter, flow, total peripheral resistance) and aortic baroreceptor activitysurrogate

Divergent heart rate responses to acute volume loading are determined by the extent of peripheral vasodilation and resulting baroreceptor activation.

Hartikainen et al. (1989) studied this question.

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