Why the study?
Does adenosine-induced hypotension aggravate myocardial ischemia in a canine model with severe coronary stenosis?
Population
14 pentobarbitone anaesthetized dogs with open-chest preparation and severe coronary stenosis causing acute…
Comparison
Adenosine-induced hypotension for 15 minutes vs Baseline state with LAD stenosis before…
Design
Preclinical
Follow-up
15 minutes
Authors
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Adenosine hypotension did not worsen ischemia in canine stenosis; leaves open human applicability pending clinical data.
Does adenosine-induced hypotension aggravate myocardial ischemia in a canine model with severe coronary stenosis?
In a canine model of acute myocardial ischemia, adenosine-induced hypotension did not worsen ECG or metabolic signs of ischemia.
Öwall et al. (1988) studied this question.
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