Why the study?
Does adenosine-receptor blockade or glycolysis blockade alter myocardial contractile function and glucose utilization during critical coronary stenosis in dogs?
Population
Anesthetized mongrel dogs with critical coronary artery stenosis established with a screw clamp on the left…
Comparison
Infusion of either 8-phenyltheophylline (3 x 10… vs Vehicle infusion
Design
Preclinical
Authors
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Supports glycolysis and adenosine in preserving ischemic contractile function; leaves open clinical translation from this animal model.
Does adenosine-receptor blockade or glycolysis blockade alter myocardial contractile function and glucose utilization during critical coronary stenosis in dogs?
Glycolysis is vital for maintaining regional myocardial contractile function during decreased O2 supply, and adenosine plays an important role in this process independent of its vasoactive properties.
Fang et al. (1997) studied this question.
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