Key result
Intracoronary adenosine deaminase slightly reduces regional myocardial blood flow distal to severe coronary stenosis.
Why the study?
Whether adenosine is required to maintain arteriolar vasodilation distal to a severe coronary stenosis was unknown.
Population
Eight closed-chest conscious pigs with severe LAD stenosis and six additional pigs
Comparison
Intracoronary adenosine deaminase infusion vs baseline and post-infusion controls
Design
Preclinical experimental study
Follow-up
20-30 minutes after stopping infusion
Authors
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Does not support adenosine as primary ischemic vasodilator; hypothesis-generating for dominant mediators before any clinical consideration.
p-value: p=<0.05
Destruction of interstitial adenosine causes only slight relative reduction in regional myocardial blood flow distal to a severe coronary stenosis, suggesting adenosine contributes only modestly to maintaining arteriolar vasodilation in this setting.
Gewirtz et al. (1983) studied Severe coronary artery stenosis (n=14). Intracoronary infusion of adenosine deaminase vs. Baseline control was evaluated on Regional myocardial blood flow (distal:circumflex epicardial flow ratio) (p=<0.05). Intracoronary infusion of adenosine deaminase caused only a slight relative reduction in regional myocardial blood flow distal to a severe coronary artery stenosis (P<0.05).
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