What question did this study set out to answer?

To determine the impact of intracoronary adenosine infusion on left ventricular contractility, tension, and myocardial blood flow in intact dogs with intact or pharmacologically inhibited adrenergic systems.

February 1, 1973The Journal of PhysiologyOpen Access

Left ventricular contractility and developed tension in the intact dog submitted to an intracoronary infusion of adenosine

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Why the study?

Does intracoronary adenosine infusion affect left ventricular contractility and developed tension in normal and propranolol-treated dogs?

Population

Anaesthetized intact dogs (normal and propranolol-treated)

Comparison

Intracoronary infusion of adenosine (150 x… vs Baseline (control values) prior to infusion

Design

Preclinical

Follow-up

50 minutes

Authors

JLJ LammerantUniversity of Namur IBI BecseiUniversity of Namur

Discussion

Member takes

Implication

Supports adenosine as coronary vasodilator without inotropic effects in dogs; leaves open effects on human ventricular function.

Key Points

To determine the impact of intracoronary adenosine infusion on left ventricular contractility, tension, and myocardial blood flow in intact dogs with intact or pharmacologically inhibited adrenergic systems.
Infused adenosine at 150 × 10⁻⁹ M/min for 50 minutes into a main branch of the left coronary artery in anesthetized normal and propranolol-treated dogs.
Evaluated hemodynamics, peak dP/dt, and tension-time index continuously, alongside measuring myocardial blood flow at 10, 30, and 50 minutes using the radioactive inert gas clearance method.
Adenosine infusion produced no detectable change in heart rate, aortic pressure, left ventricular end-diastolic pressure, time to peak dP/dt, or tension-time index in either normal or propranolol-treated animals.
Myocardial blood flow increased threefold over baseline at 10 minutes in both groups; flow remained elevated in control dogs through 50 minutes but declined by minute 50 in propranolol-treated dogs.

Structured PICO

Does intracoronary adenosine infusion affect left ventricular contractility and developed tension in normal and propranolol-treated dogs?

Population

Anaesthetized intact dogs (normal and propranolol-treated)

Intervention

Intracoronary infusion of adenosine (150 x 10(-9)M/min for 50 min) into a main branch of the left coronary artery (usually circumflex)

Comparator

Baseline (control values) prior to infusion

Outcome

Left ventricular contractility and developed tension (heart rate, aortic pressure, left ventricular end-diastolic pressure, time to peak dP/dt, peak dP/dt, and left ventricular tension-time index)surrogate

Intracoronary adenosine increases myocardial blood flow but has no direct inotropic effect on the left ventricle in intact dogs, regardless of adrenergic blockade.

Cite This Study

Lammerant et al. (1973) studied this question.

synapsesocial.com/papers/6a890f85ccf6b39be57b4d29 https://doi.org/10.1113/jphysiol.1973.sp010125

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Left ventricular contractility and developed tension in the intact dog submitted to an intracoronary infusion of adenosine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Left ventricular contractility and developed tension in the intact dog submitted to an intracoronary infusion of adenosine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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