Population
Anesthetized, open-chest dogs
Comparison
Six experimental conditions and beta-blockade vs Paired control states
Design
Preclinical
Authors
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Adenosine may link myocardial O2 consumption to coronary flow independent of beta-stimulation; hypothesis-generating in animals and leaves open human relevance.
Adenosine production responds to alterations of myocardial oxygen consumption independently of the stimulus, suggesting it may initiate changes in coronary blood flow to balance oxygen supply and demand.
Knabb et al. (1983) studied this question.
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