Why the study?
Does phenylephrine increase force of contraction and slow inward current in bovine ventricular trabeculae?
Does phenylephrine increase force of contraction and slow inward current in bovine ventricular trabeculae?
Alpha-adrenoceptor stimulation with phenylephrine produces a cyclic AMP-independent positive inotropic effect in bovine cardiac muscle by increasing slow inward calcium current and delaying its inactivation.
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Alpha-adrenergic inotropy via Ca current without cAMP in bovine ventricle; leaves open human relevance and clinical translation.
Brückner et al. (1984) studied this question.
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