March 1, 1994Journal of Cardiovascular Electrophysiology

Alpha₁‐Adrenergic Receptor Modulation of Repolarization in Canine Purkinje Fibers

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Population

Canine Purkinje fibers

Comparison

Phenylephrine with or without 4-aminopyridine or… vs Baseline/control conditions

Design

Preclinical

Authors

JLJae Ho LeeSeoul National University Bundang Hospital MRMichael R. RosenUniversity of Insubria

Discussion

Member takes

Implication

Does not yet guide alpha-agonist use in arrhythmia patients; leaves open IKr modulation mechanisms in human electrophysiology.

Structured PICO

Population

Canine Purkinje fibers

Intervention

Phenylephrine (0.1 to 10 microM) with or without 4-aminopyridine (4-AP) or WAY-123,398

Comparator

Baseline/control conditions

Outcome

Action potential duration at 90% repolarization (APD90)surrogate

The alpha-agonist mediated increase of action potential duration in canine Purkinje fibers is explained by inhibition of the delayed rectifier potassium current (Ik).

Cite This Study

Lee et al. (1994) studied this question.

synapsesocial.com/papers/6a7561caf5fc394144035bc7 https://doi.org/10.1111/j.1540-8167.1994.tb01160.x

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Alpha₁‐Adrenergic Receptor Modulation of Repolarization in Canine Purkinje Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alpha₁‐Adrenergic Receptor Modulation of Repolarization in Canine Purkinje Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider