What is the clinical evidence from this study?

Study design: Other. Population: Cardiac Arrhythmias. Intervention: Epinephrine. Primary outcome: Induction of bigeminy/coupled rhythm.

What question did this study set out to answer?

To determine the characteristics and physiological mechanisms responsible for bigeminal arrhythmias induced by low doses of epinephrine during cyclopropane anesthesia.

September 1, 1960Circulation ResearchOpen Access

Cardiac Arrhythmias Induced by Minimal Doses of Epinephrine in Cyclopropane-Anesthetized Dogs

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Key result

Minimal doses of epinephrine (0.1 to 2.0 µg./Kg.) injected into cyclopropane-anesthetized dogs consistently induced a coupled bigeminal rhythm.

Why the study?

Does minimal dose epinephrine induce cardiac arrhythmias in cyclopropane-anesthetized dogs?

Population

Dogs anesthetized with 20 per cent cyclopropane

Comparison

Epinephrine 0.1 to 2.0 µg/Kg injected in 1 minute vs Other sympathomimetic amines

Design

Preclinical

Authors

PDPETER B. DRESELUniversity of Manitoba KMKeith L. MacCannellOffice of Education MNMark NickersonNovartis (Switzerland)

Discussion

Member takes

Implication

May warrant caution with catecholamines under select anesthetics; leaves open translation to modern agents and patients.

Key Points

To determine the characteristics and physiological mechanisms responsible for bigeminal arrhythmias induced by low doses of epinephrine during cyclopropane anesthesia.
Administered 0.1 to 2.0 µg/kg of epinephrine over 1 minute to dogs anesthetized with 20% cyclopropane.
Tested comparative responses using other sympathomimetics, including phenylephrine, methoxamine, and isoproterenol, alongside the beta-blocker dichloroisoproterenol.
Assessed coupling intervals during sudden changes in atrial rate to evaluate the role of ventricular automaticity.
Epinephrine doses of 0.1 to 2.0 µg/kg induced a coupled bigeminal rhythm characterized by an exceptionally constant interval between coupled beats.
Phenylephrine consistently elicited bigeminy, methoxamine induced it rarely, and isoproterenol failed to produce the arrhythmia.
Bigeminy required systolic blood pressure elevation and sympathomimetic cardiac stimulation, while constant coupling intervals during atrial rate shifts ruled out an automatic ventricular focus.

Structured PICO

Does minimal dose epinephrine induce cardiac arrhythmias in cyclopropane-anesthetized dogs?

Population

Dogs anesthetized with 20 per cent cyclopropane.

Intervention

Epinephrine 0.1 to 2.0 µg/Kg injected in 1 minute

Comparator

Other sympathomimetic amines (phenylephrine, methoxamine, isoproterenol)

Outcome

Induction of a coupled rhythm (usually bigeminal)surrogate

Minimal doses of epinephrine can induce bigeminy in cyclopropane-anesthetized dogs, dependent on elevated systolic pressure and cardiac stimulation.

Cite This Study

DRESEL et al. (1960) studied Cardiac Arrhythmias. Epinephrine was evaluated on Induction of bigeminy/coupled rhythm. Minimal doses of epinephrine (0.1 to 2.0 µg./Kg.) injected into cyclopropane-anesthetized dogs consistently induced a coupled bigeminal rhythm.

synapsesocial.com/papers/6a6d205e2163a0a01bc2bd57 https://doi.org/10.1161/01.res.8.5.948

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Cardiac Arrhythmias Induced by Minimal Doses of Epinephrine in Cyclopropane-Anesthetized Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiac Arrhythmias Induced by Minimal Doses of Epinephrine in Cyclopropane-Anesthetized Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider